Table2. Classification of 101 genes up-regulatedby ATRA in the differentiation of NB4 cells

Accession number

Gene Name

1. Transcription Factors & DNA Binding Proteins

J04111

AP-1 (c-jun)

2 24hr^

M81750

myeloid cell nuclear differentiation antigen

2 24hr^

M97796

DNA-binding protein inhibitor ID-2*

1 24hr^

M62829

transcription factor ETR103*

1 48hr^

U10421

homeobox protein HOX-A1*

1 24hr^

L22343

nuclear phosphoprotein

1 24hr^

M69104

glucocorticoid receptor

2 24hr^

AF036892

nuclear receptor coactivator ACTR*

1 12hr^

U66574

STAT6*

1 24hr^

M97936

STAT1 ????*

2 8hr ^

X82200

Staf 50

2 12hr^

U79751

JEM*

1 48hr^

U80982

C/EBP ?*

2 12hr^

2. RNA binding protein

AF038963

RIG-I*

1 24hr ^

U18121

double-stranded RNA binding protein*

1 12hr^

3. Cytokines, chemokines and Growth Factors

M16552

thrombomodulin

1 48hr^

M24545

monocyte chemotactic protein 1

1 12hr^

M32977

vascular endothelial growth factor

1 48hr^

M92381

thymosin ?-10

2 48hr^

X06234

calgranulin (A)

1 48hr^

X06233

calgranulin (B) *

1 24hr^

M60278

heparin-binding EGF-like growth factor*

1 48hr^

Y00787

IL-8

1 12hr^

K02770

IL-1 ?*

1 24hr^

M17733

thymosin ? 4*

2 12hr^

U77035

macrophage inflammatory protein 3 ?*

2 12hr^

X13621

HNP-3defensin*

1 48hr^

U85768

myeloid progenitor inhibitory factor-1*

1 12hr^

M25316

potential lymphokine/cytokine*

1 24hr^

4. Receptors and membrane proteins

U08839

urokinase plasminogen activator receptor

1 48hr^

D10924

HM89*

2 12hr^

D10925

HM145*

1 48hr^

M59818

GCSF-R

1 8hr ^

L08187

cytokine receptor EB13

1 48hr^

U42376

RIG-E

2 8hr ^

M60346

H+-ATPase ??subunit*

1 24hr^

Z49107

galectin*

1 24hr^

X17042

hematopoetic proteoglycan core protein*

2 24hr^

J04739*

bactericidal permeability increasing protein

2 24hr^

U20350

G protein-coupled receptor V28

1 24hr^

A23013

CD52*

2 12hr^

J03143

INF-???receptor

2 12hr^

M25280

lymph node homing receptor

1 24hr^

S57235

CD68*

2 12hr^

5. Signal transduction Modulators & Effectors

AF069313

human WSB-1(RIG-C) **

2 8hr^

AF077031

human PTP(RIG-D) **

2 24hr^

D26309

LIMK kinase

1 48hr^

L05624

MAPKK 1*

1 48hr^

L13738

tyrosine-protein kinase SYK

1 48hr^

L32976

protein kinase MLK-3

1 48hr^

U30473

src-like adapter protein

1 8hr ^

A: All-trans retinoic acid.
2 denotes basal expression.
denotes upregulated signal, not inhibited by cycloheximide

Accession number

Gene Name

NB4:A

L29511

GRB2

2 72hr^

M19722

tyrosine-protein kinase FGR

1 48hr^

X06318

PKC type ?

2 12hr^

X07743

pleckstrin

2 12hr^

A31920

calmodulin

2 8hr ^

S80542

intracytoplasmic tyrosine kinase*

1 12hr^

M35416

GTP-binding protein

1 12hr^

6. IFN signalling related

X14454

interferon regulatory factor 1

1 8hr ^

U52513

RIG-G*

2 12hr^

M14660

ISG-54K*

1 12hr^

M24594

interferon-inducible 56kD protein*

1 12hr^

D00068

(2'-5') oligoadenylate synthetase

1 24hr^

M87434

2'5' oligoadenylate synthetase (71kD)

1 24hr^

7. Protein modulation

AF061736

human UCE(RIG-A) **

2 24hr^

AF061738

human LAP(RIG-B) **

2 24hr^

AF031141

ubiquitin conjugating enzyme*

2 24hr^

U67122

ubiquitin-related protein SUMO-1*

1 24hr^

X56976

ubiquitin activating enzyme E1

2 8hr ^

M59488

S100 protein ?

2 12hr^

8. Cell cycle regulators

U40343

CDK inhibitor [p19INK4d

2 24hr^

U09579

p21WAF/CIP1

1 12hr^

AF011794

cell cycle progression restoration protein*

2 48hr^

9. Apoptosis-related protein

D15057

DAD-1*

2 8hr ^

U29680

Bcl-2 related (Bfl-1); A1 protein

1 12hr^

S40706

GADD153(CHOP) *

1 8hr ^

10. Cell Surface Antigens &Adhesion Proteins

J03132

ICAM-1

2 8hr ^

J04145

CD11b

1 48hr^

L12002

CD49d

1 48hr^

M15395

CD11a

1 8hr ^

M81695

CD11C

1 12hr^

11. Metabolism

AF067174

human RD(RIG-H) **

2 12hr^

U03688

dioxin-inducible cytochrome p450

2 24hr^

M98479

transglutaminase

1 12hr^

M25665

neutrophil cytosol factor 1*

1 24hr^

U30255

phosphogluconate dehydrogenase

1 12hr^

D10040

long-chain acyl-CoA synthetase*

2 12hr^

M10036

triosephosphate isomerase

2 48hr^

S53175

NADH: ubiquinone oxidoreductase

1 24hr^

12. Unclassified

AF061739

human SIH001(RIG-J) **

2 12hr^

AF077041

human SIH002(RIG-K) **

1 8hr^

AF077040

human SIH003(RIG-L) **

2 24hr^

L54057

CLP

2 12hr^

X67698

tissue specific mRNA

2 12hr^

M83248

nephropontin*

2 12hr^

A20470

PreA-PAI-2*

1 24hr^

U31176

human ERV1

2 24hr^

X61123

BTG1

1 24hr^

D87443

human KIAA0254 gene*

2 12hr^

D87451

human KIAA0262 gene*

2 8hr ^

X04011

X-CGD gene

2 12hr^

**denotes novel genes ^ denotes upregulation signal.
1 denotes no basal expression.